Clear Stubborn Acne: Advanced Dermatology-Strength Treatment

1 Big Thing

Struggling with persistent acne that won’t go away? A prescription-strength combination of tretinoin (0.05%) and clindamycin (1%) may be the key to finally clearing your skin.

Why It Matters

Over-the-counter treatments work for some, but many people need a stronger solution. This powerful prescription formula targets acne at its source—reducing breakouts, unclogging pores, and preventing future flare-ups.

Between the Lines

Not all acne treatments are created equal. If drugstore products have failed, this dermatologist-trusted combination could be the breakthrough your skin needs.

‍

Go Deeper

Why Does Acne Keep Coming Back?

Acne isn’t just a teenage problem—it can persist well into adulthood. If you’ve tried everything from benzoyl peroxide to salicylic acid and still struggle with breakouts, there’s a reason:

• Clogged pores – Dead skin and oil trap bacteria, leading to pimples.
• Excess oil (sebum) production – Oily skin fuels breakouts and makes them harder to control.
• Bacterial overgrowth – Acne bacteria (Cutibacterium acnes) thrive in clogged pores, triggering inflammation.
• Inflammation – Red, swollen acne lesions indicate your skin is fighting an infection.

Over-the-counter products can help mild breakouts, but if acne is persistent, painful, or resistant to store-bought treatments, a prescription-strength solution is often necessary.

‍

How the Tretinoin + Clindamycin Formula Works

This prescription-only topical treatment combines two powerful acne-fighting ingredients for maximum results.

Key Ingredients & Their Role

1. Tretinoin (0.05%) – The Skin Cell Regenerator

Tretinoin is a vitamin A derivative (a type of retinoid) that accelerates skin cell turnover. It works by:

• Unclogging pores – Prevents dead skin and oil from building up.
• Reducing fine lines and scars – Improves overall skin texture.
• Fading dark spots – Helps with post-acne hyperpigmentation.
• Preventing future breakouts – Keeps pores clear before pimples form.

👉 Important Note: Tretinoin does not work overnight. Expect 8-12 weeks before significant results, and acne may worsen temporarily as skin adjusts (known as "purging").

2. Clindamycin (1%) – The Bacteria Fighter

Clindamycin is a topical antibiotic that targets acne-causing bacteria. It works by:

• Reducing inflammation – Less redness, swelling, and pain.
• Killing acne bacteria (C. acnes) – Prevents breakouts from spreading.
• Enhancing tretinoin’s effects – Works together to clear skin faster.

👉 Why It’s Better Than OTC Spot Treatments: Unlike benzoyl peroxide, clindamycin directly eliminates acne bacteria while also calming inflammation—without over-drying the skin.

‍

Effectiveness & Considerations

• ‍Tretinoin + Clindamycin is a dermatologist-recommended combo for stubborn acne.
• ‍Works for mild, moderate, and severe acne, including hormonal breakouts.
• ‍Prevents future breakouts, not just treats existing pimples.
• ‍Results take time – Expect 2-3 months of consistent use before full improvement.
• ‍Side effects may include mild dryness, redness, peeling, or irritation.

Results Timeline

• Week 1-4 – Skin may purge (temporary breakouts).
• Week 5-8 – Acne starts to clear, redness and bumps fade.
• Week 9-12 – Significant improvement, smoother and clearer skin.

👉 Important: Acne treatment requires consistency—stopping too soon can cause breakouts to return.

How to Use the Tretinoin + Clindamycin Cream

For best results, follow these application guidelines:

1. ‍Apply a pea-sized amount only to affected areas—not your whole face.
2. ‍Use at bedtime—tretinoin makes skin sensitive to sunlight.
3. ‍Wash your face with a gentle cleanser and wait 20-30 minutes before applying.
4. ‍Moisturize to reduce dryness (use a non-comedogenic moisturizer).
5. ‍Always wear sunscreen (SPF 30+) during the day—tretinoin increases sun sensitivity.
6. ‍Expect an adjustment period—mild irritation and peeling are normal at first.

👉 Best for: Stubborn, persistent acne that doesn’t respond to OTC treatments.
👉 Not for: Individuals allergic to clindamycin or with extremely sensitive skin.

‍

Why Choose a Compounded Formula?

Unlike store-bought treatments, a custom-compounded topical treatment is:

• ‍Stronger than OTC products – Tailored for stubborn acne.
• ‍Combines multiple active ingredients for maximum effectiveness.
• ‍Prescription-based – Expert-approved and formulated by trusted compound pharmacies.

👉 This treatment requires a prescription, which Well Revolution can provide.

‍

What Are the Alternatives?

If you’re looking for other ways to improve acne, consider:

• ‍Oral antibiotics (e.g., doxycycline) – For severe, inflammatory acne.
• ‍Hormonal therapy (e.g., birth control, spironolactone) – For hormonal breakouts.
• ‍Benzoyl peroxide + salicylic acid – Less effective for resistant acne but can help mild cases.
• ‍Isotretinoin (Accutane) – The strongest acne treatment, but only for severe cases.

👉 For most people, the tretinoin + clindamycin formula is the best prescription option before considering stronger alternatives.

‍

‍

How to Get Started

If you're ready to take control of your acne, Well Revolution can help you with a custom prescription and treatment through our network of pharmacy partners.

Steps to Get Your Acne Treatment Prescription

1. Free Specialist Consultation

Chat live with a Well Revolution licensed specialist for a skin assessment. A quick assessment will help establish which treatment is right for you.

2. Get a Custom Prescription

If treatment is recommended, get a prescription for a custom-compounded formula for just $50.

3. Get Your Treatment

Your prescription is sent to a Well Revolution pharmacy partner for home delivery or pick up.

‍

Clearer Skin, More Confidence

Acne is more than just a cosmetic issue—it can affect confidence, self-esteem, and mental well-being. If you’ve struggled with persistent breakouts, it’s time to try an advanced, dermatologist-recommended solution.

With the right prescription-strength formula, consistent use, and expert guidance, you can finally achieve clearer, healthier skin.

Health concerns, no matter how minor, can impact your confidence and overall well-being. If you're ready to fight stubborn acne, consult a Well Revolution specialist today for expert guidance and a personalized treatment plan.

‍